Transcriptional regulation of alpha-1 adrenergic receptors

Regulation of alpha1-adrenergic receptors (alpha1ARs) is a rapidly expanding field of study due to the involvement of these receptors in several human diseases. For example, upregulation of alpha1bAR mRNA/protein with agonist exposure has been implicated in myocardial hypertrophy. In order to understand mechanisms underlying these findings, initial studies of human alpha1bAR transcription have been completed and the primary promoter characterized. This review summarizes current knowledge regarding human alpha1bAR gene transcription and compares characteristics with other adrenergic receptor genes.