Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adhesion molecules in vernal keratoconjunctivitis

A M Abu el-Asrar1, K Geboes, S al-Kharashi

  • 1Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

The British Journal of Ophthalmology
|March 14, 1998
PubMed
Summary

Vernal keratoconjunctivitis (VKC) shows increased expression of adhesion molecules in the conjunctiva. This suggests a significant role for these molecules in the inflammatory processes underlying VKC.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Treatment of acute bacterial conjunctivitis with topical lomefloxacin 0.3% compared to topical ofloxacin 0.3.

European journal of ophthalmology·2017
Same author

Late onset posttraumatic Propionibacterium acnes endophthalmitis.

European journal of ophthalmology·2017
Same author

Decrease in tear bioavailability of ciprofloxacin in eyes with carbon containing eyeliners.

Saudi medical journal·2016
Same author

Toxoplasmosis in Saudi Arabia.

Saudi medical journal·2016
Same author

Autocrine CCL2, CXCL4, CXCL9 and CXCL10 signal in retinal endothelial cells and are enhanced in diabetic retinopathy.

Experimental eye research·2013
Same author

Prognostic factors after primary vitrectomy and perfluorocarbon liquids for bullous rhegmatogenous retinal detachment.

European journal of ophthalmology·2009

Area of Science:

  • Ophthalmology
  • Immunology
  • Cell Biology

Background:

  • Adhesion molecules are crucial for directing leucocyte populations to inflammatory sites.
  • Vernal keratoconjunctivitis (VKC) is an allergic eye condition characterized by inflammation.

Purpose of the Study:

  • To investigate the presence and distribution of key adhesion molecules in the conjunctiva of patients with active VKC.
  • To compare adhesion molecule expression in VKC patients with healthy controls.

Main Methods:

  • Conjunctival biopsy specimens from VKC patients and normal controls were analyzed.
  • A panel of monoclonal antibodies (mAbs) was used to detect intercellular adhesion molecule-1 (ICAM-1), ICAM-3, lymphocyte function associated antigen-1 (LFA-1), very late activation antigen-4 (VLA-4), vascular cell adhesion molecule-1 (VCAM-1), and endothelial leucocyte adhesion molecule-1 (ELAM-1).

Related Experiment Videos

Main Results:

  • VKC conjunctiva exhibited a marked increase in cells expressing adhesion molecules compared to controls.
  • Strong expression of ICAM-1, LFA-1, ICAM-3, and VLA-4 was observed on epithelial and stromal cells in VKC.
  • VCAM-1 and ELAM-1 were induced on vascular endothelial cells in VKC patients.

Conclusions:

  • The elevated expression of adhesion molecules in VKC conjunctiva is significantly associated with the inflammatory infiltrate.
  • These findings indicate that increased adhesion molecule expression plays a critical role in the pathogenesis of VKC.