Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Diuretics and osteoporosis]

L Rejnmark1, L Mosekilde, F Andreasen

  • 1Klinisk Farmakologisk Center, Arhus Universitet.

Nordisk Medicin
|March 14, 1998
PubMed
Summary
This summary is machine-generated.

Thiazide diuretics benefit bone health by reducing calcium loss and lowering fracture risk. Loop diuretics may harm bones by increasing calcium excretion, necessitating caution in long-term use.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fracture risk in patients treated with amiodarone or digoxin for cardiac arrhythmias: a nation-wide case-control study.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2006
Same author

Predictive value of parathyroid scintigraphy in the preoperative evaluation of patients with primary hyperparathyroidism.

Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society·2006
Same author

Effects of parathyroid hormone alone or in combination with antiresorptive therapy on bone mineral density and fracture risk--a meta-analysis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2006
Same author

Methotrexate, azathioprine, cyclosporine, and risk of fracture.

Calcified tissue international·2006
Same author

Proton pump inhibitors, histamine H2 receptor antagonists, and other antacid medications and the risk of fracture.

Calcified tissue international·2006
Same author

Fracture risk associated with use of nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, and acetaminophen and the effects of rheumatoid arthritis and osteoarthritis.

Calcified tissue international·2006
Same journal

[Nordisk Medicine 1929-1998. Thanks and farewell!].

Nordisk medicin·1999
Same journal

[Scientific fraud and misconduct--need for comprehensive terminology].

Nordisk medicin·1999
Same journal

[Labor-market for Scandinavian physicians in the year 2000--dearth or surplus?].

Nordisk medicin·1999
Same journal

[Internet in consultation--headed for trouble?].

Nordisk medicin·1999
Same journal

[Interpretation of questionnaires. An translation method problem].

Nordisk medicin·1999
Same journal

[Assessment of patients' health status--review of the literature and assessment methods].

Nordisk medicin·1999
See all related articles

Area of Science:

  • Nephrology
  • Endocrinology
  • Bone Metabolism

Context:

  • Diuretics are commonly prescribed for various medical conditions.
  • Different classes of diuretics have varying effects on calcium homeostasis.
  • The impact of diuretics on bone health is a significant clinical consideration.

Purpose:

  • To investigate the contrasting effects of thiazide and loop diuretics on calcium excretion and bone metabolism.
  • To explore the potential mechanisms behind the observed effects on bone mineral density and fracture risk.
  • To provide insights into the safe and effective use of diuretics in patients at risk for osteoporosis.

Summary:

  • Thiazide diuretics decrease renal calcium excretion, leading to higher bone mineral density and reduced hip fracture risk, potentially by lowering parathyroid hormone (PTH) and vitamin D levels.

Related Experiment Videos

  • Loop diuretics increase urinary calcium excretion, with studies suggesting associations with decreased bone mineral density and increased fracture risk, though this remains controversial.
  • The precise mechanisms for thiazide's bone-protective effects, such as reduced PTH-stimulated bone resorption, require further elucidation.

    • Impact:

    • Findings suggest thiazide diuretics may be safely used for bone health, while long-term use of loop diuretics warrants caution, especially in osteoporotic patients.
    • Highlights the need for further research into optimal diuretic dosing for sustained hypocalciuric effects and understanding loop diuretic adverse effects on bone.
    • Informs clinical practice regarding diuretic selection and monitoring in patients concerned about bone health and osteoporosis.