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A rhino mutant originating in KK mice
1Lead Optimization Research Laboratory, Tanabe Seiyaku Co. Ltd., Saitama, Japan.
Experimental Animals
|March 14, 1998
Summary
A new KK-rhino mouse mutant exhibits hairless traits and wrinkled skin, resembling the rhino mouse. This unique strain may possess a gene for hairlessness and inherited traits, including diabetes.
Area of Science:
- Genetics
- Dermatology
- Mouse Models
Background:
- A hairless trait was observed in a black-haired KK (KK-C) mouse colony in 1991.
- This hairless condition presented with wrinkled and pimpled skin, characteristic of the 'rhino' mouse phenotype.
Purpose of the Study:
- To conduct a clinicopathological and histopathological investigation of the newly identified KK-rhino mouse mutant.
- To characterize the genetic basis and inherited traits of the KK-rhino mouse.
Main Methods:
- Chronological clinicopathological and histopathological examinations of the KK-rhino mouse.
- Preliminary mating examinations to assess the mode of inheritance for the hairless trait.
Main Results:
- The KK-rhino mouse displays a distinct hairless phenotype with characteristic skin abnormalities.
- Preliminary genetic analysis suggests the hairless trait is linked to the [hrrh] gene.
- The mutant strain exhibits a unique combination of 'rhino' and 'diabetes' traits.
Conclusions:
- The KK-rhino mouse represents a novel mutant strain with significant potential for studying hair follicle development and related genetic disorders.
- This unique mouse model offers opportunities to investigate the co-inheritance of dermatological and metabolic conditions.