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[Endogenous Aspergillus endophthalmitis in AIDS]
M Petersen1, C Althaus, R Santen
1Augenklinik der Medizinischen Einrichtungen, Heinrich-Heine-Universität, Düsseldorf.
Background:
We present the course of an endogenous Aspergillus endophthalmitis in a 38-year-old HIV-positive man. HISTORY AND CLINICAL SIGNS: The first examination because of a sudden visual loss in the right eye showed a central subretinal infiltration, peripheral vascular sheeting and retinal hemorrhages.
Therapy And Outcome:
In spite of high-dose systemic antifungal therapy we could not prevent the penetration of the posterior wall of the eye and infiltration of adjacent orbital structures. Enucleation had to be performed.
Conclusions:
In case of scleral involvement in Aspergillus endophthalmitis the necessity of enucleation has to be considered.
Insights
Endogenous Aspergillus endophthalmitis in an HIV-positive man led to orbital invasion despite antifungal treatment. Enucleation was necessary due to scleral involvement, highlighting the importance of considering this outcome.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Mycology
Background:
- Case study of endogenous Aspergillus endophthalmitis in a 38-year-old HIV-positive male.
- Initial presentation included sudden vision loss, subretinal infiltration, vascular changes, and retinal hemorrhages in the right eye.
Purpose of the Study:
- To describe the clinical course and management of endogenous Aspergillus endophthalmitis.
- To emphasize the implications of scleral involvement in this condition.
Main Methods:
- Clinical case presentation.
- Review of treatment response to high-dose systemic antifungal therapy.
Main Results:
- Despite aggressive antifungal treatment, the infection penetrated the posterior ocular wall and invaded adjacent orbital structures.
- Enucleation (eye removal) was ultimately required.
Conclusions:
- Scleral involvement in Aspergillus endophthalmitis is a critical factor.
- Enucleation should be strongly considered when scleral invasion occurs in Aspergillus endophthalmitis.