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Urinary organic acids in man. I. Normal patterns

A M Lawson, R A Chalmers, R W Watts

    Clinical Chemistry
    |August 1, 1976
    PubMed
    Summary
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    Researchers identified novel urinary polyhydroxy acids in healthy individuals. This discovery establishes a baseline for diagnosing organic acidurias in patients, aiding in metabolic disorder research.

    Area of Science:

    • Biochemistry
    • Metabolomics
    • Human Physiology

    Background:

    • Understanding normal human metabolism is crucial for identifying disease states.
    • Urinary organic acids serve as biomarkers for various metabolic conditions.
    • Previous studies recognized a range of urinary organic acids, but gaps in knowledge remained.

    Purpose of the Study:

    • To characterize the qualitative pattern of urinary acidic metabolites in normal individuals.
    • To establish a reference profile for identifying abnormal organic acid excretion.
    • To discover and identify previously unreported urinary compounds.

    Main Methods:

    • Qualitative analysis of urinary acidic metabolites.
    • Identification of polyhydroxy acids, including aldonic and deoxyaldonic acids.

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  • Comparison with previously known urinary organic acids.

    • Main Results:

    • A series of previously unreported urinary polyhydroxy acids (aldonic and deoxyaldonic acids) were identified.
    • These novel compounds were found in the urine of normal individuals.
    • Previously recognized urinary organic acids were also observed, confirming the analytical approach.

    Conclusions:

    • The identified polyhydroxy acids represent new components of the normal human urinary metabolome.
    • This study provides a foundational dataset for the diagnosis of organic acidurias.
    • Further research into the metabolic origins of these novel acids is warranted.