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Placental metastasis from maternal primitive neuroectodermal tumor

H Sakurai¹, N Mitsuhashi, Y Ibuki

¹Department of Radiology and Radiation Oncology, School of Medicine, Gunma University, Maebashi, Japan.

American Journal of Clinical Oncology

|March 14, 1998

Summary

This rare case report details placental metastasis from a maternal primitive neuroectodermal tumor (PNET). The infant survived, highlighting potential outcomes in such rare obstetric oncology cases.

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Area of Science:

Obstetrics and Gynecology
Oncology
Pathology

Background:

Maternal primitive neuroectodermal tumors (PNETs) are rare.
Placental metastasis from PNET is an exceptionally uncommon event.

Observation:

A 33-year-old pregnant woman with unresectable retroperitoneal PNET died 28 days after admission.
Her neonate, delivered via C-section, showed no signs of disease and survived to one year.
Pathological examination revealed intervillous placental metastasis from the maternal PNET.

Findings:

The maternal tumor exhibited characteristics of PNET, including small round cells and Homer-Wright rosettes.
Immunohistochemistry confirmed tumor cells positive for neuron-specific enolase.
Microscopic placental analysis confirmed intervillous metastasis from the maternal PNET.

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Implications:

This case represents a potential first report of placental metastasis from a maternal PNET.
It underscores the importance of thorough pathological examination in obstetric oncology.
Further research into the mechanisms and outcomes of PNET metastasis during pregnancy is warranted.