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Published on: February 15, 2018
[Infants of diabetic mothers (IDM). I -- Macrosomia and growth factors]
G Martín Carballo1, G Fernández Cano, C Grande Aragón
1Servicio de Endocrinología, Hospital Infantil La Paz, Madrid.
Objective:
The objective of this study was to determine the incidence of macrosomia in infants of diabetic mothers (IDM) and to analyze its possible correlation with insulin, C-peptide, growth hormone (GH) and IGF-I levels in umbilical cord blood.
Patients And Methods:
A prospective study of 58 IDM and 58 control newborns (33 males and 25 females in both groups) was carried out.
Results:
The incidence of macrosomia was 25.8% in the IDM group and 61.5% in the IIDDM group (infant of insulin-dependent diabetic mother) compared to 5% in the control group. There was a positive correlation between maternal Hgb Alc levels in the third trimester of gestation and insulin and C-peptide levels with newborn weight in the IDM group (especially in the IIDDM group). IGF-I levels were positively correlated with newborn weight in both control and IDM groups. There was no correlation between GH and IGF-I levels in any group.
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