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[Infants of diabetic mothers (IDM). II -- Fibronectin and perinatal morbidity]

G Martín Carballo1, R Codoceo Alquila, G Fernández Cano

  • 1Servicio de Endocrinología, Hospital Infantil La Paz, Madrid.

Anales Espanoles De Pediatria
|March 14, 1998
PubMed

Insights

Fibronectin levels in umbilical cord blood do not differ between infants of diabetic mothers and healthy newborns. Therefore, fibronectin is not a useful marker for evaluating perinatal complications in these infants.

Area of Science:

  • Neonatal research
  • Endocrinology
  • Biochemistry

Background:

  • Maternal diabetes mellitus can lead to adverse perinatal outcomes.
  • Infants of diabetic mothers (IDM) are at increased risk for various complications.
  • Biomarkers are needed to assess perinatal health in IDM.

Purpose of the Study:

  • To measure fibronectin levels in the umbilical cord blood of IDM.
  • To investigate the correlation between fibronectin levels and perinatal pathology in IDM.

Main Methods:

  • Prospective study design.
  • Inclusion of 58 IDM and 58 control newborns.
  • Measurement of fibronectin levels in umbilical cord blood.

Main Results:

  • No significant difference in fibronectin levels was observed between IDM and control groups.
  • No sex-based differences in fibronectin levels were found.
  • Higher perinatal morbidity was noted in the IDM group, but fibronectin levels did not correlate with these pathologies.

Conclusions:

  • Fibronectin levels in umbilical cord blood are not a reliable indicator for perinatal evaluation in infants of diabetic mothers.
  • Further research may be needed to identify effective biomarkers for IDM complications.
Abstract

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