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[Clinical course and prognostic factors in newborns with very low birth weight]
C Tapia Collados1, M A Feret Siguile, J L Serrano Martínez
1Sección de Neonatología, Unidad de Salud Mental Infantil, Hospital General Universitario de Alicante.
Insights
Survival rates for infants under 1,500 grams birth weight were 69.87%, with severe neurodevelopmental sequelae affecting 22.6%. Lower birth weight significantly increased the risk of severe sequelae.
Area of Science:
- Neonatalogy
- Pediatric Neurology
- Developmental Pediatrics
Background:
- Infants born with very low birth weight (VLBW), defined as <1,500 grams, face significant risks for mortality and neurodevelopmental impairments.
- Long-term outcomes for VLBW infants require careful monitoring to understand the incidence and severity of developmental sequelae.
Purpose of the Study:
- To evaluate the survival rates and neurodevelopmental sequelae in a cohort of 249 infants with birth weights under 1,500 grams.
- To identify factors associated with adverse outcomes in this high-risk population.
Main Methods:
- A retrospective study of 249 infants treated between 1986-1991 with birth weights <1,500 grams.
- Follow-up assessments were conducted at corrected ages of 3, 6, 10, 18, 36 months, with results reported up to 18 months.
- Neurodevelopmental sequelae were categorized by disability degree (moderate and severe).
Main Results:
- Overall survival was 69.87%; 38.7% for infants <1,000 grams and 84.7% for those >1,000 grams.
- 22.6% of infants experienced sequelae, with 11.6% moderate and 10.9% severe.
- Severe sequelae incidence varied by birth weight: 25.8% (<1,000g), 13.9% (1,000-1,249g), and 1.6% (1,250-1,500g).
Conclusions:
- Intracranial hemorrhage, hyperbilirubinemia, assisted ventilation, and persistent ductus arteriosus were significantly associated with sequelae.
- No significant differences in sequelae were found related to multiple pregnancy, seizures, sepsis, or neonatal hypoxia.
Objective:
We report the results of survival and incidence of neurodevelopmental sequelae in a group of 249 infants treated in our hospital between 1986-91, whose birth weight was under 1,500 grams.
Method:
We perform a follow-up at corrected ages of 3, 6, 10, 18, 36 months and 5 years thought results only included children followed until 18. Sequelae were classified in three groups, according to the disability degree.
Results:
Survival resulted to be 69.87% (174), 38.7% for the group under 1,000 grams and 84.7% for those over 1,000 grams. Sequelae were present in 22.6% (11.6% moderate and 10.9% severe). The incidence of severe sequelae was very different on basis of the birth weight, 25.8% for children under 1,000 grams, 13.9% for 1,000-1,249 grams and 1.6% for 1,250-1,500 grams.
Conclusions:
Intracranial haemorrhage, hyperbilirubinemia, assisted ventilation and persistence of ductus arteriosus were significantly associated sequelae. We didn't find differences with respect to multiple pregnancy, seizures, sepsis or neonatal hypoxia.