Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glycated proteins in diabetes

A J Furth1

  • 1Oxford Research Unit, Open University, England, UK.

British Journal of Biomedical Science
|March 21, 1998
PubMed
Summary

Protein glycation by sugars like glucose and fructose forms harmful products linked to diabetic complications. Monitoring glycation in vivo is challenging, but antiglycation therapies offer potential benefits.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of protein-bound carbonyl groups in the formation of advanced glycation endproducts.

Biochimica et biophysica acta·1997
Same author

Mixed dimers formed by crosslinking of native and glycated proteins in the absence of free sugar.

Biochemical and biophysical research communications·1996
Same author

Fructation induced cross-linking of beta-lactoglobulin and lysozyme.

Biochemical Society transactions·1995
Same author

Metal-catalysed oxidation and post-Amadori reactions of serum albumin and other model proteins.

Biochemical Society transactions·1993
Same author

The role of bound lipid and transition metal in the formation of fluorescent advanced glycation endproducts by human serum albumin.

Biochemical Society transactions·1993
Same author

A colorimetric microassay for glycated collagen based on the thiobarbituric acid method.

Clinica chimica acta; international journal of clinical chemistry·1992

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Background:

  • Protein glycation is a non-enzymatic reaction involving sugars.
  • Glucose and fructose are primary dietary sugars that can glycate proteins.
  • Glycation products are implicated in the pathogenesis of diabetes mellitus.

Purpose of the Study:

  • To discuss the effects of protein glycation by glucose and fructose.
  • To emphasize glycation products found in diabetic subjects and prepared in vitro.
  • To review molecular damage, diabetic complications, monitoring challenges, and antiglycation therapy.

Main Methods:

  • Literature review of glycation effects and products.
  • Analysis of molecular damage from Amadori products and advanced glycation end-products (AGEs).
  • Critical evaluation of in vivo glycation monitoring and antiglycation strategies.

Main Results:

  • Glycation by glucose and fructose produces Amadori products and AGEs.
  • These products cause molecular damage linked to diabetic complications.
  • In vivo glycation monitoring presents significant difficulties.

Conclusions:

  • Protein glycation contributes to diabetic complications through molecular damage.
  • Antiglycation therapies are a potential therapeutic avenue.
  • Further research is needed for effective in vivo glycation monitoring and treatment.

Related Experiment Videos