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CD5+ low-grade marginal zone B-cell lymphomas with localized presentation
E Ballesteros1, B M Osborne, A Y Matsushima
1Department of Pathology, Columbia-Presbyterian Medical Center, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA.
The American Journal of Surgical Pathology
|March 21, 1998
Summary
Rare CD5 positive marginal zone B-cell lymphomas (MZBCLs) can present with localized disease, differing from typical widespread presentations. This finding expands understanding of MZBCL phenotypes and clinical behavior.
Area of Science:
- Hematology
- Oncology
- Immunopathology
Background:
- Marginal zone B-cell lymphomas (MZBCLs) are typically CD5 negative low-grade lymphomas.
- Rare cases of CD5 positive MZBCL (CD5+ MZBCL) have been reported, often with widespread disease.
Observation:
- This study presents four new cases of CD5+ MZBCL.
- Three cases were mucosa-associated lymphoid tissue (MALT) lymphomas (lungs, conjunctiva, uterus).
- One case was a monocytoid B-cell lymphoma (cervical lymph node).
Findings:
- All four patients presented with localized disease.
- Peripheral blood counts were normal, and bone marrow staging showed no involvement in three patients.
- Southern blot analysis did not reveal bc11 or bc12 rearrangements in analyzed cases.
Implications:
- CD5+ MZBCL can exhibit an atypical phenotype.
- Unlike most reported cases, these CD5+ MZBCLs were clinically localized at presentation.
- This suggests a subset of CD5+ MZBCL may have a more indolent clinical course.