Related Experiment Video
Updated: Jul 29, 2026

08:52
Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells
Published on: June 13, 2018
Ameloblastic fibrosarcoma in a bull
E A Sartin1, R C Weiss, A N Baird
1Department of Pathobiology, College of Veterinary Medicine, Auburn University, AL 36849-5519, USA.
Journal of Comparative Pathology
|March 21, 1998
Summary
A rare malignant odontogenic neoplasm was identified in a bull, presenting as a destructive mass in the mandible. This tumor, previously undescribed in animals, shares characteristics with human ameloblastic fibrosarcoma.
Area of Science:
- Veterinary Pathology
- Comparative Oncology
- Odontogenic Neoplasms
Background:
- Odontogenic tumors arise from tooth-forming tissues.
- Ameloblastic fibrosarcoma is a rare malignant odontogenic tumor in humans.
- Neoplasms in livestock can have significant economic and welfare impacts.
Observation:
- A 7-year-old bull presented with a locally invasive and destructive mass involving the right mandible.
- Histological examination revealed islands and cords of benign odontogenic epithelium within a malignant mesenchymal cell population.
Findings:
- The observed tumor exhibited morphological features consistent with ameloblastic fibrosarcoma.
- This represents the first documented case of ameloblastic fibrosarcoma in an animal species.
Implications:
- This finding expands the known spectrum of odontogenic neoplasms in animals.
- It highlights the importance of comparative pathology in understanding rare tumors.
- Further research may elucidate the specific etiology and behavior of this neoplasm in cattle.

