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Related Experiment Videos

Treated versus untreated major depressive episodes

J Angst1

  • 1Zürich University Psychiatric Hospital, Switzerland.

Psychopathology
|March 21, 1998
PubMed
Summary
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In major depressive episodes (MDE), treated females are overrepresented and experience more severe symptoms. Surprisingly, treatment may lead to a more favorable course compared to untreated individuals.

Area of Science:

  • Psychiatry and Mental Health
  • Epidemiology of Mood Disorders

Background:

  • Major Depressive Episodes (MDE) represent a significant public health concern.
  • Previous hypotheses suggested females, more severe episodes, chronic courses, and serious consequences characterize treated MDE.
  • The Zürich cohort study provides longitudinal data on MDE in an enriched population sample.

Purpose of the Study:

  • To test the hypothesis regarding the characteristics of treated MDE cases in a community sample.
  • To investigate sex distribution, episode severity, chronicity, and consequences in treated versus untreated MDE.
  • To compare treated and untreated MDE subjects with controls regarding family history, age of onset, coping, and personality traits.

Main Methods:

  • Longitudinal cohort study of 591 subjects examined five times between ages 20 and 35.

Related Experiment Videos

  • Diagnosis of MDE based on DSM-IV criteria.
  • Analysis of demographic, clinical, treatment history, family history, and personality data (aggression, neuroticism).

    • Main Results:

    • Longitudinal prevalence of MDE was 20.2% (26.7% females, 13.5% males).
    • Of 173 MDE subjects, 66 were treated; 82% of treated cases were female, compared to a 1.2:1 F/M ratio in untreated subjects.
    • Treated cases showed greater severity, more days in depression, higher suffering, and more impairment, but surprisingly a trend towards a more favorable course than untreated cases. Treated cases also differed in aggression and neuroticism scores.

    Conclusions:

    • The hypothesis is partially supported: females are overrepresented among treated MDE cases, who also exhibit greater severity and impairment.
    • Contrary to expectations, treated MDE cases showed a trend towards a more favorable course than untreated individuals.
    • Treated MDE patients exhibit distinct personality profiles (aggression, neuroticism) compared to untreated individuals and controls.