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T1 effects in sequential dynamic susceptibility contrast experiments

J M Levin1, L L Wald, M J Kaufman

  • 1Brain Imaging Center, Harvard Medical School, Belmont, Massachusetts, 02178, USA.

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|May 2, 1998
PubMed
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Residual gadolinium contrast effects in dynamic susceptibility contrast MRI are likely due to susceptibility, not T1, issues. An initial contrast dose can minimize these spurious hemodynamic estimates.

Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Neuroimaging
  • Pharmacology

Background:

  • Residual effects from initial gadolinium contrast boluses are observed in sequential dynamic susceptibility contrast (DSC) MRI.
  • These effects reach a steady state but their cause remains unclear.
  • They can lead to inaccurate hemodynamic parameter estimations in brain activation studies.

Purpose of the Study:

  • To investigate the potential influence of T1 effects on residual gadolinium contrast agent observations in DSC-MRI.
  • To differentiate between T1 and susceptibility effects contributing to these residual signals.
  • To identify methods for mitigating spurious hemodynamic measurements.

Main Methods:

  • Experiments involving variations in T1 weighting during DSC-MRI acquisition.

Related Experiment Videos

  • Serial regional T1 measurements were performed.
  • Comparison of signal changes attributed to T1 relaxation versus magnetic susceptibility.

    • Main Results:

    • Minimal evidence for significant residual T1 effects was found.
    • Susceptibility effects were identified as the likely underlying cause of the observed residual signals.
    • An initial saturation dose of gadolinium contrast agent was shown to minimize these residual effects.

    Conclusions:

    • Residual effects in DSC-MRI are primarily driven by susceptibility phenomena, not T1 relaxation.
    • Understanding and mitigating these susceptibility effects is crucial for accurate hemodynamic parameter quantification.
    • Implementing an initial contrast saturation dose is a viable strategy to reduce artifacts in dynamic susceptibility contrast MRI.