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Related Experiment Videos

Figure-ground activity in primary visual cortex is suppressed by anesthesia

V A Lamme1, K Zipser, H Spekreijse

  • 1Graduate School of Neurosciences, Department of Medical Physics, Academic Medical Center, University of Amsterdam, and The Netherlands Ophthalmic Research Institute, P.O. Box 12141, 1100 AC Amsterdam, The Netherlands. v.lamme@amc.uva.nl

Proceedings of the National Academy of Sciences of the United States of America
|April 18, 1998
PubMed
Summary

Neural activity in the primary visual cortex (V1) shows distinct processing for visual perception. Contextual modulation, crucial for figure-ground perception, requires an awake brain, unlike basic receptive field properties.

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Area of Science:

  • Neuroscience
  • Visual Perception
  • Cortical Processing

Background:

  • Neurons in the primary visual cortex (V1) have small receptive fields (RFs), leading to localized visual analysis.
  • Contextual modulation integrates local information into a global percept, aligning with perceptual interpretation.

Purpose of the Study:

  • To investigate if contextual modulation in V1 depends on the animal's state (awake vs. anesthetized).
  • To determine if contextual modulation is functionally distinct from local RF processing.

Main Methods:

  • Recorded multi-unit activity from V1 of awake and anesthetized monkeys viewing textured displays with segregated figure-ground regions.
  • Isolated contextual modulation by varying RF position relative to figure-ground while keeping RF stimulation constant.

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  • Compared V1 activity between awake and anesthetized states.

    • Main Results:

    • Contextual modulation unfolded spatially and temporally, mirroring the figure-ground percept in awake animals.
    • Figure-ground related modulatory activity was suppressed in anesthetized animals.
    • Basic RF tuning properties remained unaffected by anesthesia.

    Conclusions:

    • Contextual modulation in V1 is functionally distinct from local RF properties.
    • V1 exhibits separate activity regimes dependent on the animal being awake or anesthetized, suggesting distinct underlying mechanisms.