Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Parallel dermal subcompartments for modeling chemical absorption

R L Bookout1, D W Quinn, J N McDougal

  • 1Air Force Institute of Technology, Wright-Patterson AFB, OH 45433, USA.

SAR and QSAR in Environmental Research
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Detection of oxidative species and low-molecular-weight DNA in skin following dermal exposure with JP-8 jet fuel.

Journal of applied toxicology : JAT·2001
Same author

Short-Term dermal absorption and penetration of chemicals from aqueous solutions: theory and experiment.

Risk analysis : an official publication of the Society for Risk Analysis·2001
Same author

Dermal exposure to m-xylene leads to increasing oxidative species and low molecular weight DNA levels in rat skin.

Journal of biochemical and molecular toxicology·2001
Same author

Effect of JP-8 jet fuel on molecular and histological parameters related to acute skin irritation.

Toxicology and applied pharmacology·2001
Same author

Pericardial mesothelioma: the diagnostic dilemma of misleading images.

The Annals of thoracic surgery·2000
Same author

Assessment of skin absorption and penetration of JP-8 jet fuel and its components.

Toxicological sciences : an official journal of the Society of Toxicology·2000
Same journal

Mapping toxicity pathways of per- and polyfluoroalkyl substances using interpretable classification-based machine learning models.

SAR and QSAR in environmental research·2026
Same journal

Structure-based identification of inhibitory compounds targeting M32 metallocarboxypeptidase of <i>Leishmania donovani</i>.

SAR and QSAR in environmental research·2026
Same journal

Multiscale computational evaluation of marine fungal metabolites containing iminohydantoin-like scaffolds as anti-Alzheimer drug candidates.

SAR and QSAR in environmental research·2026
Same journal

Conformational landscapes and binding free energies of multitarget phytochemicals reveal molecular recognition mechanisms in colorectal cancer-associated proteins.

SAR and QSAR in environmental research·2026
Same journal

AI-driven QSAR modelling and virtual screening in the discovery of selective dopamine D<sub>2</sub> receptor ligands.

SAR and QSAR in environmental research·2026
Same journal

Integrating machine learning and pharmacogenomics for biomarker discovery, identification and prioritization of potential drug candidates in ovarian cancer.

SAR and QSAR in environmental research·2026
See all related articles

New physiologically-based pharmacokinetic (PBPK) models improve predictions of Dibromomethane absorption through rat skin. These enhanced models offer better accuracy and physiological detail for chemical exposure assessments.

Area of Science:

  • Toxicology
  • Pharmacokinetics
  • Dermal Absorption

Background:

  • Understanding chemical absorption via skin is crucial for risk assessment.
  • Physiologically-based pharmacokinetic (PBPK) models simulate chemical uptake and distribution.
  • Validated PBPK models enable cross-species extrapolation for human exposure prediction.

Purpose of the Study:

  • To develop novel PBPK models for predicting Dibromomethane (DBM) blood concentrations in rats following dermal vapor exposure.
  • To enhance a previously developed homogeneous skin model by incorporating skin appendages and layered structures.
  • To improve the physiological realism and predictive accuracy of dermal absorption models.

Main Methods:

  • Development of two new PBPK models with parallel skin subcompartments (appendages) and layered subcompartments (skin strata).

Related Experiment Videos

  • Simulation of DBM dermal vapor exposure in rats using the new PBPK models.
  • Comparison of model predictions against experimental data.
  • Sensitivity analysis to identify critical model parameters.

    • Main Results:

    • The new PBPK models demonstrated improved prediction accuracy compared to the original homogeneous skin model.
    • The enhanced models provide a more physiologically descriptive representation of the skin.
    • Sensitivity analysis identified key parameters influencing DBM absorption and distribution.

    Conclusions:

    • The developed PBPK models offer a significant advancement in simulating dermal chemical absorption.
    • These models enhance the ability to extrapolate findings across different species, doses, and exposure durations.
    • Further validation will solidify their utility in toxicological risk assessment.