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[Vascular wall and diabetes mellitus: what complications and why?]
1Centre Hospitalier Universitaire d'Angers, France.
Insights
Diabetics face triple the cardiovascular event risk compared to non-diabetics. This heightened risk, linked to both microvascular and macrovascular complications, requires further investigation for effective management strategies.
Area of Science:
- Cardiology
- Endocrinology
- Diabetology
Context:
- Cardiovascular disease (CVD) risk is significantly elevated in diabetic individuals.
- Diabetic macrovascular complications are more common, occur earlier, and have a worse prognosis.
- The relationship between hyperglycemia and microvascular disease is established in insulin-dependent diabetes.
Purpose:
- To highlight the increased cardiovascular risk in diabetics.
- To differentiate between microvascular and macrovascular complications in diabetes.
- To underscore the lack of established strategies for reducing cardiovascular risk in non-insulin-dependent diabetes, particularly concerning hyperglycemia levels.
Summary:
- Diabetics exhibit a three-fold higher absolute risk of cardiovascular events compared to non-diabetics.
- This increased risk stems from both specific microvascular complications and more frequent, earlier, and severe macrovascular complications.
- While hyperglycemia's link to microvascular disease is clear in insulin-dependent diabetes, effective strategies to mitigate cardiovascular risk in non-insulin-dependent diabetes, considering hyperglycemia, remain undefined.
Impact:
- Emphasizes the critical need for targeted cardiovascular risk reduction strategies in diabetic populations.
- Informs clinical practice regarding the distinct challenges posed by microvascular and macrovascular complications in diabetes.
- Highlights a gap in current therapeutic approaches for non-insulin-dependent diabetes, particularly in managing hyperglycemia-related cardiovascular risks.
Abstract:
The absolute risk of cardiovascular events is three times higher in diabetics than in non-diabetics. This risk can be due either to specific microvascular complications, or to macrovascular complications, which are non-specific but more frequent, earlier, and of poorer prognosis in diabetics than in non-diabetics. The link between hyperglycaemia and microvascular diseases has been well established in insulin-dependent diabetes. Conversely, no specific treatment strategy has been established to decrease cardiovascular risk in non-insulin-dependent diabetes, especially taking into consideration the level of hyperglycaemia.