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Antigen processing: HLA-DO--a hitchhiking inhibitor of HLA-DM
1Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA. pjensen@bimcore.emory.edu
Current Biology : CB
|March 21, 1998
Abstract:
Recent studies have revealed that the conserved major histocompatibility complex class II molecule, HLA-DO, inhibits the class II antigen-processing pathway. HLA-DO, expressed in only a subset of antigen-presenting cells, binds HLA-DM and blocks HLA-DM-catalyzed peptide loading of class II molecules.