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Glucose intolerance in familial combined hyperlipidaemia. EUFAM study group
J Vakkilainen1, K V Porkka, I Nuotio
1Department of Medicine, University of Helsinki, Finland.
European Journal of Clinical Investigation
|March 21, 1998
Summary
Familial combined hyperlipidaemia (FCHL) increases glucose intolerance risk. Affected individuals show impaired glucose tolerance and higher diabetes prevalence, independent of lipid type or obesity in men.
Area of Science:
- Cardiovascular Genetics
- Metabolic Disorders
- Human Genetics
Background:
- Familial combined hyperlipidaemia (FCHL) is a prevalent hereditary lipid disorder.
- Hypertriglyceridaemia, a component of FCHL, is linked to impaired glucose metabolism and insulin resistance.
Purpose of the Study:
- To investigate glucose tolerance in individuals with familial combined hyperlipidaemia (FCHL) across various lipid phenotypes.
- To determine the prevalence of impaired glucose tolerance and diabetes within FCHL pedigrees.
Main Methods:
- Studied 253 affected family members and 92 spouses from 33 Finnish FCHL pedigrees.
- Utilized oral glucose tolerance tests to assess glucose metabolism.
- Analyzed glucose tolerance in relation to lipid phenotypes (normal, IIA, IIB, IV) and adjusted for BMI, waist circumference, and age.
Main Results:
- Affected FCHL family members exhibited significantly higher glucose area under the curve compared to non-affected members (P < 0.001).
- Impaired glucose tolerance and diabetes were more prevalent in affected individuals across all lipid phenotypes.
- Specific prevalences of normal glucose tolerance were 94.0% (normal), 80.0% (IIA), 54.3% (IIB), and 58.5% (IV).
Conclusions:
- Individuals with FCHL demonstrate a higher degree of glucose intolerance than their unaffected relatives.
- In men with FCHL, glucose intolerance was not associated with specific lipid phenotypes or explained by obesity.