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Gastroduodenal permeability in Crohn's disease
A Püspök1, G Oberhuber, J Wyatt
1Department of Gastroenterology and Hepatology, University of Vienna, Austria. andreas.puespoek@akh-wien.ac.at
European Journal of Clinical Investigation
|March 21, 1998
Summary
Gastric permeability is elevated in Crohn's disease patients, mirroring small intestine findings. Combined with intestinal permeability, sucrose excretion accurately predicts upper gastrointestinal Crohn's involvement.
Area of Science:
- Gastroenterology
- Inflammatory Bowel Disease Research
- Clinical Investigation
Background:
- Investigated gastric permeability in 100 Crohn's disease patients using sucrose excretion.
- Compared results with histological findings and lactulose-mannitol ratio for intestinal permeability.
- Focused on upper gastrointestinal tract involvement in Crohn's disease.
Purpose of the Study:
- To assess gastroduodenal permeability in Crohn's disease patients.
- To correlate gastric permeability with histological findings and intestinal permeability.
- To determine the predictive value of sucrose excretion for upper GI Crohn's involvement.
Main Methods:
- Prospective study involving 100 Crohn's disease patients.
- Oesophagogastroduodenoscopy with biopsies.
- Measurement of sucrose excretion and lactulose-mannitol ratio.
- Exclusion of Helicobacter pylori-positive patients.
Main Results:
- Significantly higher gastroduodenal permeability in Crohn's disease patients (P < 0.00001).
- Sucrose excretion alone did not predict microscopic upper GI inflammation.
- Combined increased gastroduodenal and intestinal permeability predicted histological upper GI involvement with 86% likelihood.
Conclusions:
- Gastroduodenal permeability is increased in a significant proportion of Crohn's disease patients.
- Elevated sucrose excretion, alongside an increased lactulose-mannitol ratio, is highly predictive of histological gastroduodenal involvement.
- Findings parallel increased permeability observed in the small intestine.