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Related Experiment Videos

Decrease of S100 beta protein in serum of patients with amyotrophic lateral sclerosis

M Otto1, E Bahn, J Wiltfang

  • 1Neurologische Klinik und Poliklinik, Universität Göttingen, Germany.

Neuroscience Letters
|March 21, 1998
PubMed
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Serum S100 beta protein levels did not differ significantly in amyotrophic lateral sclerosis (ALS) patients versus controls. However, S100 beta levels decreased over time, suggesting it may track ALS disease progression.

Area of Science:

  • Neuroscience
  • Biochemistry

Background:

  • Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder impacting motor neurons.
  • The exact cause of ALS remains unknown, with astrogliosis being a key pathological feature.
  • Biomarkers are needed to monitor disease progression in ALS.

Purpose of the Study:

  • To evaluate serum S100 beta protein levels as a potential biomarker for astroglia in ALS patients.
  • To assess if S100 beta levels correlate with disease progression in ALS.

Main Methods:

  • Serum S100 beta protein was measured in 41 ALS patients and 32 controls.
  • Longitudinal measurements were performed on 12 ALS patients over a minimum of 6 months.

Main Results:

Related Experiment Videos

  • No significant difference in S100 beta levels was found between ALS patients and controls (P = 0.11).
  • A clear decrease in serum S100 beta levels was observed as the disease progressed.
  • S100 beta protein exhibits nerve growth factor activity.

    • Conclusions:

    • Serum S100 beta levels do not appear to be a reliable diagnostic marker for ALS at a single time point.
    • The observed decrease in S100 beta suggests a loss of nerve growth stimulation in ALS.
    • Repetitive S100 beta measurements may serve as an objective marker for tracking ALS disease progression.