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Laparoscopic hepatic lobectomy in the porcine model
J S Wu1, S M Strasberg, D R Luttmann
1Department of Surgery, Section of Hepatobiliary Pancreatic Surgery, Washington University School of Medicine, One Barnes Hospital Plaza, St. Louis, MO 63110, USA.
Surgical Endoscopy
|April 16, 1998
Summary
Laparoscopic left hepatic lobectomy is feasible in pigs using an abdominal wall lift device. Further clinical trials are needed to confirm safety and efficacy in humans.
Area of Science:
- Minimally Invasive Surgery
- Surgical Innovation
- Animal Models in Research
Background:
- Laparoscopic hepatectomy reports are limited, mostly to wedge resections.
- Assessing feasibility of laparoscopic hepatic lobectomy is crucial.
Purpose of the Study:
- To evaluate the technical feasibility of laparoscopic hepatic lobectomy.
- To assess the safety and outcomes in a porcine model.
Main Methods:
- Eight pigs underwent laparoscopic left hepatic lobectomy using an abdominal wall lift device.
- Ultrasonic dissector, staplers, and argon beam coagulator were employed for dissection and hemostasis.
- Pre- and postoperative liver enzymes and blood counts were monitored.
Main Results:
- Mean operating time was 131 minutes, clamp time 39 minutes.
- Four intraoperative complications occurred but were managed successfully.
- No postoperative complications, deaths, bile leaks, or abscesses were observed.
Conclusions:
- Laparoscopic left hepatic lobectomy is technically feasible in a porcine model.
- An abdominal wall lift device provides adequate exposure for the procedure.
- Clinical trials are necessary to establish safety and limitations for human application.