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Related Experiment Videos

D1- versus D2-receptor modulation of visuospatial working memory in humans

U Müller1, D Y von Cramon, S Pollmann

  • 1Max-Planck-Institute of Cognitive Neuroscience, 04103 Leipzig, Germany.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|April 16, 1998
PubMed
Summary

Pergolide, a mixed D1/D2 receptor agonist, improved visuospatial working memory in humans. Bromocriptine, a D2 agonist, did not, suggesting a key role for D1 receptors in cognitive function.

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Pharmacology

Background:

  • Dopamine receptors are implicated in cognitive functions, including working memory.
  • Previous research suggests differential roles for D1 and D2 dopamine receptor subtypes in working memory.

Purpose of the Study:

  • To investigate the role of dopamine D1 and D2 receptors in human working memory.
  • To examine the differential effects of pergolide (mixed D1/D2 agonist) and bromocriptine (selective D2 agonist) on visuospatial working memory.

Main Methods:

  • A placebo-controlled, cross-over study involving 64 healthy young adults.
  • Administration of pergolide or bromocriptine, with domperidone pretreatment to mitigate side effects.
  • A visuospatial delayed matching task assessing working memory performance at 2, 8, and 16-second delays.

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Main Results:

  • Both error rates and reaction times increased significantly with longer memory delays.
  • Pergolide significantly facilitated visuospatial working memory performance across delays.
  • Bromocriptine did not show a significant effect on working memory performance.

Conclusions:

  • Findings support a preferential role for prefrontal dopamine D1 receptors in modulating human working memory.
  • The results align with existing animal and neuroanatomical data on dopamine receptor function in cognition.