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The stimulation of the mitochondrial permeability transition by dihydrolipoate and alpha-lipoate
N E Saris1, A Karjalainen, V V Teplova
1Department of Medical Chemistry, University of Helsinki, Finland.
Biochemistry and Molecular Biology International
|March 21, 1998
Abstract:
The effect of alpha-lipoate and dihydrolipoate on the mitochondrial permeability transition was investigated. Both substances promoted the permeability transition in isolated rat liver mitochondria and in permeabilized hepatocytes, dihydrolipoate most potently in spite of it being a dithiol. The stimulation was prevented by Cyclosporin A or hydroxybutyltoluene but not by ascorbate. It is suggested that the greater potency of dihydrolipoate could be due to formation of a radical.