Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Volume therapy in the critically ill: is there a difference?

J Boldt1, M Müller, D Mentges

  • 1Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt Ludwigshafen, Germany.

Intensive Care Medicine
|March 21, 1998
PubMed
Summary

Hydroxyethylstarch solution (HES) showed no disadvantages compared to human albumin (HA) for 5-day fluid replacement in critically ill patients. HES demonstrated improved hemodynamics and is a cost-effective alternative for prolonged volume therapy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Guidelines--a misleading path for the physician?].

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS·1999
Same author

Changes in blood lymphocyte populations after multiple trauma: association with posttraumatic complications.

Critical care medicine·1999
Same author

[Therapy recommendation--"Viagra and NO donors"].

Der Urologe. Ausg. A·1999
Same author

Cerebral blood flow velocity and carbon dioxide vasoreactivity during gamma-hydroxybutyrate/fentanyl anaesthesia in non-neurosurgical patients.

European journal of anaesthesiology·1999
Same author

Plasma levels of selectins and interleukins in cardiovascular surgery using cardiopulmonary bypass.

The Thoracic and cardiovascular surgeon·1999
Same author

[Experiences fo three year's routine operation of an anesthesia information management system (AIMS) at a university clinic in Giessin].

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS·1999

Area of Science:

  • Critical Care Medicine
  • Pharmacology
  • Nephrology

Background:

  • Concerns exist regarding prolonged hydroxyethylstarch solution (HES) use in critically ill patients.
  • Human albumin (HA) is a common alternative for volume replacement therapy.

Purpose of the Study:

  • To compare the effects of 5-day volume replacement with HES versus HA on hemodynamics, laboratory data, and organ function in critically ill patients.
  • To evaluate the cost-effectiveness of HES compared to HA.

Main Methods:

  • Prospective, randomized study in a surgical intensive care unit.
  • 150 trauma patients and 150 sepsis patients received either 10% HES or 20% HA for 5 days.
  • Hemodynamic parameters, laboratory data, and organ function were monitored daily.

Related Experiment Videos

Main Results:

  • No significant differences in mortality or incidence of pulmonary, renal, or hepatic failure between HES and HA groups.
  • HES group showed higher cardiac index, oxygen delivery, and oxygen consumption compared to HA group.
  • Lactate concentrations decreased in HES-sepsis patients; HES therapy was significantly less costly than HA.

Conclusions:

  • Five-day volume therapy with 10% HES is not disadvantageous compared to 20% HA in ICU patients.
  • HES may improve hemodynamics and represents a cost-effective alternative for prolonged fluid therapy.
  • HES is a valuable and cheaper alternative to albumin for critically ill patients.