Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The human serotonin transporter gene polymorphism--basic research and clinical implications

A Heils1, R Mössner, K P Lesch

  • 1Department of Psychiatry, University of Würzburg, Federal Republic of Germany.

Journal of Neural Transmission (Vienna, Austria : 1996)
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

No association between peripheral serotonin-gene-related DNA methylation and brain serotonin neurotransmission in the healthy and depressed state.

Clinical epigenetics·2024
Same author

Venlafaxine's therapeutic reference range in the treatment of depression revised: a systematic review and meta-analysis.

Psychopharmacology·2023
Same author

The challenge of palmoplantar pustulosis therapy: Are Interleukin-23 inhibitors an option?

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

A multicentre open-label study of apremilast in palmoplantar pustulosis (APLANTUS).

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

Serotonin deficiency induced after brain maturation rescues consequences of early life adversity.

Scientific reports·2021
Same author

DNA methylation in the 5-HTT regulatory region is associated with CO<sub>2</sub>-induced fear in panic disorder patients.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·2020
Same journal

Stress and resilience: cortisol hypo-response to acute stress in non-resilient individuals.

Journal of neural transmission (Vienna, Austria : 1996)·2026
Same journal

Dopamine supersensitivity psychosis: a critical evaluation of diagnostic validators.

Journal of neural transmission (Vienna, Austria : 1996)·2026
Same journal

A refined protocol for the large-scale production of high-quality cerebral organoids.

Journal of neural transmission (Vienna, Austria : 1996)·2026
Same journal

Investigating smiling asymmetries in Parkinson's disease through the whistle-smile reflex.

Journal of neural transmission (Vienna, Austria : 1996)·2026
Same journal

The German Parkinson expert meetings.

Journal of neural transmission (Vienna, Austria : 1996)·2026
Same journal

Changes in leukocytes and CRP in different treatments of major depression.

Journal of neural transmission (Vienna, Austria : 1996)·2026
See all related articles

A serotonin transporter gene (5-HTT) promoter polymorphism influences gene expression and is linked to anxiety-related behaviors. This genetic variation impacts mood and cognition, potentially contributing to psychiatric disorders.

Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • The serotonergic system, specifically the midbrain raphe system, modulates mood, emotion, and cognition.
  • Dysregulation of serotonin transporter (5-HTT) expression is implicated in psychiatric disorders, particularly affective spectrum disorders.

Purpose of the Study:

  • To isolate and characterize the 5'-regulatory region of the serotonin transporter gene.
  • To investigate the functional impact of genetic variations within this promoter region on gene expression and their association with behavioral traits.

Main Methods:

  • Cloning and functional analysis of the 5'-regulatory region of the serotonin transporter gene.
  • Systematic screening for length variations and promoter activity assays.
  • Population association studies to correlate genetic polymorphisms with behavioral traits.

Related Experiment Videos

Main Results:

  • Identification of a genetic polymorphism in the 5'-regulatory promoter region of the serotonin transporter gene (5-HTT).
  • This 5-HTT gene polymorphism exhibits allelic variation in transcriptional activity and protein expression.
  • The 5-HTT gene promoter polymorphism accounts for 4-5% of population variation in anxiety-related behaviors.

Conclusions:

  • A specific polymorphism in the serotonin transporter gene promoter significantly influences gene expression.
  • This genetic variation is associated with population differences in anxiety-related behaviors.
  • The findings highlight the role of serotonergic system genetics in psychiatric disorder pathogenesis and behavioral traits.