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Catechol-O-methyltransferase genotype and susceptibility to Parkinson's disease in Japan. Short communication
A Yoritaka1, N Hattori, H Yoshino
1Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Journal of Neural Transmission (Vienna, Austria : 1996)
|January 1, 1997
Abstract:
We report -108Met/Val polymorphism of the COMT gene in Japanese patients with Parkinson's disease (PD). The allele frequency for -108Val was higher in PD patients compared with controls, although the differences did not reach the statistical significance. However, the frequency of -108Val homozygotes was significantly higher in PD patients (56.8%) than in control subjects (44.2%), and heterozygotes of -108Met/Val were less in PD. COMT gene polymorphism may constitute a genetic risk factor for PD among Japanese.