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Related Experiment Videos

Histopathologic prognostic indicators for renal cell carcinoma

B Delahunt1

  • 1Wellington School of Medicine, University of Otago, Department of Pathology, Wellington South, New Zealand.

Seminars in Diagnostic Pathology
|March 21, 1998
PubMed
Summary

Prognostic markers for renal cell carcinoma (RCC) show inconsistent results. Tumor stage and high nuclear grade are linked to poor survival, while proliferation markers consistently predict outcomes in RCC patients.

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Area of Science:

  • Oncology
  • Urology
  • Pathology

Background:

  • Prognostic marker assessment for renal cell carcinoma (RCC) yields conflicting results.
  • Tumor stage, particularly extrarenal spread, correlates with poor patient survival in RCC.
  • The prognostic value of tumor size, venous invasion, and grading systems in RCC remains debated.

Purpose of the Study:

  • To review and synthesize the evidence on prognostic markers for renal cell carcinoma (RCC).
  • To identify consistently reliable prognostic indicators for RCC patient outcomes.
  • To clarify the debated significance of various staging and grading parameters in RCC.

Main Methods:

  • Review of prospective and retrospective studies on RCC prognostic markers.
  • Analysis of associations between tumor characteristics (stage, grade, size, invasion) and patient survival.

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  • Evaluation of proliferation markers, angiogenesis, morphometry, and gene expression in RCC prognosis.

    • Main Results:

    • Tumor stage and high nuclear grade, including sarcomatoid differentiation, are associated with poorer RCC survival.
    • Tumor proliferation markers (e.g., Ki-67) demonstrate consistent association with RCC patient survival.
    • Other markers like angiogenesis and morphometry show inconsistent prognostic value across studies.

    Conclusions:

    • Tumor stage and grade are important prognostic factors in renal cell carcinoma (RCC).
    • Tumor proliferation markers offer consistent predictive value for RCC outcomes.
    • Further consensus is needed for several other potential prognostic parameters in RCC.