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[Nocturnal enuresis as a manifestation of autocoidosis]

Iu V Natochin, A A Kuznetsova

    Terapevticheskii Arkhiv
    |January 1, 1997
    PubMed

    Insights

    Diclofenac-sodium treatment normalized night-time urination in children with nocturnal enuresis by reducing fluid and salt excretion. This suggests nocturnal enuresis may stem from increased local autocoid production in the kidneys.

    Area of Science:

    • Nephrology
    • Pediatrics
    • Pharmacology

    Background:

    • Nocturnal enuresis is common in children.
    • Enuretic children exhibit higher night diuresis and free water reabsorption.
    • Increased nocturnal excretion of sodium, calcium, and magnesium ions is observed in enuretic children.

    Purpose of the Study:

    • To investigate the role of autocoids in nocturnal enuresis.
    • To evaluate the efficacy of diclofenac-sodium in treating nocturnal enuresis.

    Main Methods:

    • A study involving 30 children with nocturnal enuresis and 20 healthy controls (aged 6-15 years).
    • Administration of diclofenac-sodium before bedtime to enuretic patients.
    • Monitoring diuresis, natriuresis, and enuresis episodes.

    Main Results:

    • Diclofenac-sodium inhibited cyclooxygenase and decreased prostaglandin production.
    • Treatment led to normalization of diuresis and natriuresis.
    • Nocturnal enuresis episodes were eliminated in the treated group.

    Conclusions:

    • Nocturnal enuresis is associated with increased autocoid production in the thick ascending Henle loop, leading to elevated saluresis and diuresis.
    • A specific form of nocturnal diuresis may be linked to local autocoid hyperproduction.
    • Diclofenac-sodium shows promise in managing nocturnal enuresis by targeting autocoid pathways.

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