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[Increased IL-2 and sIL-2R in sera of infants with HTLV-I infection from mother]
1Department of Microbiology, Tokyo Metropolitan Research Laboratory of Public Health.
Insights
Maternal Human T-cell Leukemia Virus type-1 (HTLV-I) infection can transmit to newborns. Elevated Interleukin-2 (IL-2) and soluble IL-2 Receptor (sIL-2R) levels in infants may indicate HTLV-I infection.
Area of Science:
- Virology
- Immunology
- Pediatrics
Context:
- Human T-cell Leukemia Virus type-1 (HTLV-I) is a retrovirus known to infect adults and can be transmitted vertically from mother to child.
- Early detection of HTLV-I infection in newborns is crucial for monitoring and potential intervention.
- Previous studies have explored various diagnostic methods for HTLV-I, but specific early biomarkers in infected infants require further investigation.
Purpose:
- To investigate the correlation between specific cytokine concentrations and HTLV-I infection in children born to infected mothers.
- To evaluate the potential of Interleukin-2 (IL-2), soluble IL-2 Receptor (sIL-2R), and Interferon-gamma (IFN-gamma) as biomarkers for pediatric HTLV-I infection.
Summary:
- A cohort of 123 children born to HTLV-I infected mothers was monitored from 1990-1996.
- Four children were confirmed to have HTLV-I infection via PCR, Western Blot Assay (WB), and Immunofluorescence Assay (IFA).
- Analysis revealed increased concentrations of IL-2 and sIL-2R in infected children's sera, while IFN-gamma showed no correlation.
Impact:
- The findings suggest that elevated levels of IL-2 and sIL-2R could serve as potential early diagnostic markers for HTLV-I infection in newborns.
- This research contributes to understanding the immunological response to HTLV-I in early life.
- Identifying reliable biomarkers can facilitate timely diagnosis and management of pediatric HTLV-I cases.
Abstract:
In our laboratory, children born to women are known to be infected with Human T-cell Leukemia Virus type-1 (HTLV-I) have been followed using, detect of gene by PCR and antibody by Western Blot Assay (WB) and Immunofluorescence Assay (IFA) test from 1990 through 1996. Four children out of 123 delivery cases have been confirmed to be infected with HTLV-I. We analyzed the correlation between the concentration of cytokines (IL-2, sIL-2R, IFN-gamma) and HTLV-I infection. IL-2 and sIL-2R in sera increased after HTLV-I infection. There was no correlation between the concentration of IFN-gamma and HTLV-I infection. These result suggested that detection of IL-2 and sIL-2R might be the marker of HTLV-I infection.