Related Experiment Video

Updated: Aug 18, 2026

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure
09:37

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Published on: December 2, 2014

[Comparative characteristics of left ventricular remodeling in dilatation cardiomyopathy and ischemic disease]

A S Sisakian1, G A Eganian, G G Kamalov

  • 1Kafedra vnutrennikh bolezneĭ No. 1 Erevanskogo gosudarstvennogo meditsinskogo universiteta.

Klinicheskaia Meditsina
|January 1, 1997
PubMed

Insights

Left ventricular remodelling contributes to heart failure in dilated cardiomyopathy and ischemic heart disease. The dobutamine test helps differentiate these conditions by revealing lower functional reserve in dilated cardiomyopathy.

Area of Science:

  • Cardiology
  • Heart Failure Pathophysiology
  • Cardiac Imaging

Background:

  • Left ventricular remodelling is a key factor in progressive circulatory insufficiency.
  • Stereotypic structural changes occur in the left ventricle during end-stage heart failure.
  • Differentiating dilated cardiomyopathy (DCMP) from ischemic cardiomyopathy is crucial for treatment.

Purpose of the Study:

  • To investigate the role of left ventricular remodelling in heart failure.
  • To compare the functional reserve of contractility in DCMP versus ischemic cardiomyopathy.
  • To assess the utility of the dobutamine test in echocardiographic diagnosis.

Main Methods:

  • Echocardiography was used to assess left ventricular geometry and contractility.
  • The dobutamine stress test was employed to evaluate cardiac functional reserve.
  • Comparative analysis between patients with DCMP and ischemic cardiomyopathy.

Main Results:

  • Left ventricular remodelling is implicated in both DCMP and ischemic heart disease.
  • Terminal cardiac failure shows stereotypic changes in left ventricular geometry.
  • Dobutamine testing demonstrated significantly lower global and segmental contractility reserve in DCMP compared to ischemic cardiomyopathy.

Conclusions:

  • Left ventricular remodelling is a common pathway in heart failure progression.
  • The dobutamine test can aid in distinguishing DCMP from ischemic cardiomyopathy based on functional reserve.
  • Echocardiographic assessment with dobutamine challenge offers diagnostic value in complex cardiac cases.

More Related Videos

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents07:26

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure07:13

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure

Published on: April 30, 2020

Related Concept Videos

Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...