Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Narcolepsy]

T Shimizu1

  • 1Department of Neuropsychiatry, Akita University School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|March 21, 1998
PubMed
Summary
This summary is machine-generated.

Narcolepsy, a sleep disorder causing uncontrollable sleepiness and cataplexy, is linked to specific human leukocyte antigen (HLA) genes in Japanese populations. Further research is needed to confirm if narcolepsy is an immunological disorder.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart.

Biochemical and biophysical research communications·1992
Same author

Endotoxin transduces Ca2+ signaling via platelet-activating factor receptor.

FEBS letters·1992
Same author

Physiological evidence for involvement of a kinesin-related protein during anaphase spindle elongation in diatom central spindles.

The Journal of cell biology·1992
Same author

Biased reading frames of pre-existing DH--JH coding joints and preferential nucleotide insertions at VH--DJH signal joints of excision products of immunoglobulin heavy chain gene rearrangements.

The EMBO journal·1992
Same author

Relation between the biologic activities and chemical structures of synthetic microbial lipopeptide analogs in mice.

Molecular biotherapy·1992
Same author

Anti-erythrocyte membrane antibodies detected in sera of dogs naturally infected with Babesia gibsoni.

The Journal of veterinary medical science·1992
Same journal

[Development of novel therapeutics for multiple myeloma and improvement of drug lag].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Clinical pharmacy services to patients of immunomodulatory drugs].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Therapeutic drug monitoring of the new anti-myeloma drugs in the treatment of multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Prognostic value of minimal residual disease assessment using next-generation sequencing in multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[The evaluation of minimal residual disease in multiple myeloma by an allele-specific oligonucleotide real-time PCR].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Evaluation of minimal residual disease in myeloma by multiparametric flow cytometry].

Nihon rinsho. Japanese journal of clinical medicine·2019
See all related articles

Area of Science:

  • Neurology
  • Immunology
  • Genetics

Context:

  • Narcolepsy is a chronic neurological sleep disorder characterized by excessive daytime sleepiness and cataplexy.
  • Prevalence in Japanese populations ranges from 0.16% to 0.59%, with significant patient handicap.
  • The exact cause of narcolepsy remains unknown, impacting patient quality of life.

Purpose:

  • To explore the potential link between specific human leukocyte antigen (HLA) genotypes and narcolepsy.
  • To investigate the possibility of narcolepsy being an autoimmune disorder based on genetic associations.
  • To review current pharmacological treatments for narcolepsy symptoms.

Summary:

  • A strong association has been identified between specific HLA genotypes (DR15, QQ6, DRB1*1501, DRB5*0101, DQB1*0602, DQA1*0102) and narcolepsy in the Japanese population.

Related Experiment Videos

  • This genetic link suggests a potential immunological basis for narcolepsy, although direct evidence is currently lacking.
  • Pharmacological interventions include methylphenidate and pemoline for sleepiness, and tricyclic antidepressants for cataplexy, sleep paralysis, and hallucinations.

    • Impact:

    • Establishes a significant genetic marker for narcolepsy, particularly in the Japanese population.
    • Highlights the need for further immunological studies to elucidate the pathogenesis of narcolepsy.
    • Informs clinical practice regarding symptomatic management of narcolepsy using available medications.