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Related Experiment Videos

Candida dubliniensis: an emerging opportunistic pathogen

D Sullivan1, D Coleman

  • 1Department of Oral Surgery, Oral Medicine and Oral Pathology, School of Dental Science, University of Dublin, Trinity College, Ireland. djsullvn@tcd.ie

Current Topics in Medical Mycology
|March 21, 1998
PubMed
Summary
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A new fungal species, Candida dubliniensis, has been identified, primarily affecting HIV-infected individuals with oral candidiasis. This opportunistic pathogen shows distinct genetic differences from Candida albicans.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Molecular Biology

Background:

  • Opportunistic fungal infections are increasing, particularly in individuals with acquired immunodeficiency syndrome (AIDS).
  • Candida albicans is a primary fungal pathogen, often causing oral candidiasis in HIV-infected patients.
  • Emerging Candida species, including atypical strains, are increasingly reported in various patient groups.

Purpose of the Study:

  • To characterize novel atypical Candida albicans strains isolated from HIV-infected patients with oral candidiasis.
  • To determine if these atypical strains represent a distinct species.
  • To investigate the genetic and phylogenetic relationship of these isolates to known Candida species.

Main Methods:

  • Phenotypic characterization including germ tube and chlamydospore formation, and growth at 42°C.

Related Experiment Videos

  • Carbohydrate assimilation pattern analysis.
  • DNA fingerprinting techniques and karyotype analysis.
  • Ribosomal RNA sequence comparison for phylogenetic analysis.

    • Main Results:

    • Atypical isolates exhibited unusual carbohydrate assimilation and poor growth at 42°C, differentiating them from C. albicans.
    • DNA fingerprinting and karyotype analysis revealed distinct genomic organization compared to C. albicans.
    • Phylogenetic analysis based on rRNA sequences confirmed C. dubliniensis as a separate species, closely related to C. albicans.
    • C. dubliniensis has been identified globally, mainly in the oral cavities of HIV-infected individuals, often causing recurrent infections.

    Conclusions:

    • Candida dubliniensis is a newly identified fungal species.
    • This species is phenotypically similar but genetically distinct from Candida albicans.
    • C. dubliniensis is an emerging opportunistic pathogen, particularly in HIV-infected populations, and its role in recurrent infections warrants further investigation.