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Lysine clonixinate vs. paracetamol/codeine in postepisiotomy pain
A R De los Santos1, M I Martí, D Espinosa
1School of Medicine, Department of Medicine, Universidad de Buenos Aires, Argentina.
Acta Physiologica, Pharmacologica Et Therapeutica Latinoamericana : Organo De La Asociacion Latinoamericana De Ciencias Fisiologicas Y [De] La Asociacion Latinoamericana De Farmacologia
|March 21, 1998
Summary
Lysine Clonixinate (LC) and Paracetamol/Codeine (PC) equally relieved postepisiotomy pain in new mothers. Both analgesics demonstrated rapid onset and high patient satisfaction, with minimal side effects reported.
Area of Science:
- Obstetrics and Gynecology
- Pharmacology
- Pain Management
Background:
- Postepisiotomy pain is a common concern for primiparae women.
- Effective pain management is crucial for postpartum recovery and well-being.
Purpose of the Study:
- To compare the analgesic efficacy of Lysine Clonixinate (LC) versus a Paracetamol/Codeine (PC) association for moderate-to-severe postepisiotomy pain.
- To evaluate the onset and duration of pain relief, patient satisfaction, and safety profiles of both treatments.
Main Methods:
- A double-blind, randomized study involving 131 primiparous women with postepisiotomy pain.
- Patients received either LC 125 mg or Paracetamol 500 mg + Codeine 30 mg every 6 hours for 24 hours.
- Pain intensity was assessed using a Visual Analog Scale (VAS) at baseline and at 1, 2, 6, and 24 hours post-administration.
Main Results:
- Both LC and PC significantly reduced spontaneous and walking pain within 24 hours (P < 0.0001).
- No significant differences in pain reduction were observed between the LC and PC groups.
- Analgesic action onset within 30 minutes was reported by 54% of LC patients and 55% of PC patients.
- 95% of LC patients and 96% of PC patients reported total or partial pain relief on the first day.
- Both treatments were well-tolerated, with only one case of mild nausea in the LC group.
Conclusions:
- Lysine Clonixinate and Paracetamol/Codeine association are equally effective for managing moderate-to-severe postepisiotomy pain.
- Both treatments offer rapid onset of action and high patient satisfaction.
- The safety profiles of both analgesics are favorable for this patient population.