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The Women's Interagency HIV Study. WIHS Collaborative Study Group

S E Barkan1, S L Melnick, S Preston-Martin

  • 1New England Research Institutes, Watertown, MA, USA.

Epidemiology (Cambridge, Mass.)
|March 21, 1998
PubMed
Summary
This summary is machine-generated.

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The Women's Interagency HIV Study established a large U.S. cohort of women with and without human immunodeficiency virus (HIV) infection. This cohort provides a valuable resource for studying HIV disease progression and pathogenesis.

Area of Science:

  • Epidemiology
  • Infectious Diseases
  • Public Health

Background:

  • The Women's Interagency HIV Study (WIHS) is the largest U.S. cohort of women with human immunodeficiency virus (HIV).
  • It includes a comparison cohort of HIV-seronegative women, totaling over 2,600 participants.
  • The study enrolled a hard-to-reach population, with over half of participants living below poverty levels.

Purpose of the Study:

  • To describe the methodology, training, and quality assurance of the WIHS.
  • To characterize the demographic and HIV exposure risk profiles of the study population.
  • To establish the WIHS cohort as a resource for future HIV research.

Main Methods:

  • Cohort study design with enrollment from October 1994 to November 1995.
  • Data collection across six clinical consortia and 23 sites in the United States.

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  • Standardized data collection on demographics, HIV status, and exposure risks.

    • Main Results:

    • The cohort comprises 2,058 HIV-seropositive and 568 HIV-seronegative women.
    • Participants were diverse in age (16-73 years) and ethnicity (Hispanic, African-American, White).
    • Key HIV exposure risks included injection drug use and heterosexual contact.

    Conclusions:

    • The WIHS cohort is demographically similar to nationally reported cases of AIDS in U.S. women.
    • This well-characterized cohort offers a significant opportunity for research on HIV disease.
    • Future studies can investigate HIV pathogenesis and disease progression within this population.