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Lp(a) in hypertensive patients

M Catalano1, E Perilli, G Carzaniga

  • 1Research Center on Vascular Diseases, University of Milan, L. Sacco Hospital, Italy.

Journal of Human Hypertension
|March 21, 1998
PubMed
Summary

Essential arterial hypertension patients exhibit elevated lipoprotein(a) (Lp(a)) levels, a key risk factor for cardiovascular disease. This suggests Lp(a) may independently increase atherosclerosis risk in hypertensive individuals.

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Area of Science:

  • Cardiovascular Medicine
  • Lipidology
  • Hypertension Research

Background:

  • Lipoprotein(a) (Lp(a)) is a recognized risk factor for cardiovascular diseases.
  • Limited research exists on Lp(a) levels in essential arterial hypertension.
  • Hypertension and dyslipidemia are significant risk factors for atherosclerotic vascular diseases.

Purpose of the Study:

  • To quantify serum Lp(a) and lipid profile parameters in untreated essential hypertensive patients.
  • To compare Lp(a) and lipid levels between hypertensive patients and healthy controls.
  • To investigate potential correlations between Lp(a) and lipid parameters in hypertension.

Main Methods:

  • Cross-sectional study comparing 123 essential hypertensive patients with 89 matched controls.

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  • Measurement of serum Lp(a), total cholesterol (TC), triglycerides (TG), and VLDL-C.
  • Matching criteria included age, sex, BMI, and smoking status.

    • Main Results:

    • Hypertensive patients showed significantly higher plasma concentrations of Lp(a), TC, TG, and VLDL-C compared to controls (P < 0.01).
    • No significant difference in Lp(a) levels was observed between sexes.
    • Lp(a) did not correlate with other measured lipid profile parameters.

    Conclusions:

    • Hypertension is frequently associated with dyslipidemia.
    • Elevated Lp(a) levels, even within the normal range, may act as an independent risk factor for atherosclerosis in hypertensive individuals.
    • Higher Lp(a) may contribute to increased cardiovascular disease incidence in essential hypertension.