Related Experiment Videos
Brain lactate and N-acetylaspartate in pediatric AIDS encephalopathy
1Department of Neurology, New York University School of Medicine, North Shore University Hospital, Manhasset 11030, USA.
AJNR. American Journal of Neuroradiology
|March 21, 1998
Abstract:
Two children with acquired immunodeficiency syndrome (AIDS) and progressive encephalopathy underwent MR spectroscopy before and after antiretroviral therapy. Initial MR spectroscopy of the basal ganglia region showed decreased N-acetylaspartate (NAA)/creatine (Cr) and a lactate peak. After therapy, there was improvement in NAA/Cr and an absence of the abnormal lactate peak. We suggest that decreased NAA/Cr in AIDS is reversible, that brain lactate might correlate with inflammation, and that MR spectroscopy can be useful in treatment trials.