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Leukemia cutis with prominent giant cell reaction
F K Baksh1, D Nathan, W Richardson
1Department of Pathology, Eastern Virginia Medical School, Norfolk 23507, USA.
The American Journal of Dermatopathology
|March 21, 1998
Summary
Leukemia cutis can mimic chronic granulomatous inflammation due to giant cells. This case highlights the importance of considering myeloid leukemia in skin lesions with immature myeloid cells, even with granulomatous features.
Area of Science:
- Dermatopathology
- Hematology
- Oncology
Background:
- Leukemia cutis, a neoplastic infiltration of the skin by leukemic cells, can present with diverse histopathological features.
- Giant cell reactions in skin biopsies can sometimes obscure the underlying neoplastic process.
Observation:
- A skin lesion initially diagnosed as chronic granulomatous inflammation was found to have a prominent giant cell component.
- Histopathological examination revealed numerous Langhans-type giant cells alongside a significant infiltrate of immature myeloid cells.
Findings:
- The immature myeloid cells in the skin infiltrate were positive for chloroacetate esterase, lysozyme, and CD 68.
- Peripheral blood and bone marrow examinations confirmed the progression to acute myeloid leukemia.
Implications:
- This case underscores the diagnostic challenge posed by leukemia cutis mimicking inflammatory conditions.
- Accurate histopathological and hematological evaluation is crucial for the timely diagnosis and management of myeloid leukemia with cutaneous involvement.