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Soluble intercellular adhesion molecule-1 in newborn infants

I Phocas1, A Sarandakou, G Giannaki

  • 1Second Department of Obstetrics and Gynaecology, Areteion University Hospital, Athens, Greece.

European Journal of Pediatrics
|March 21, 1998
PubMed

Insights

Neonatal serum soluble intercellular adhesion molecule-1 (sICAM-1) significantly increases during the first month of life. This suggests a developing neonatal immune system response in healthy infants.

Area of Science:

  • Neonatal immunology
  • Biomarkers of immune activation

Background:

  • Soluble intercellular adhesion molecule-1 (sICAM-1) is an early marker of immune response.
  • Understanding sICAM-1 levels in neonates is crucial for assessing immune system development.

Purpose of the Study:

  • To evaluate the impact of increasing postnatal age on serum sICAM-1 levels in healthy newborns.
  • To assess sICAM-1 as a marker of immune activation in early neonatal life.

Main Methods:

  • Serum sICAM-1 was measured using EIA in 43 healthy neonates and 20 healthy adults.
  • Measurements were taken on the 1st, 5th, and 30th day of life.
  • Factors like gestational age and mode of delivery were considered.

Main Results:

  • Neonatal serum sICAM-1 significantly increased from day 1 to day 30 (137.3 to 415.0 ng/ml).
  • Day 1 sICAM-1 levels were lower than in adults, while day 30 levels were higher.
  • Early sICAM-1 levels were influenced by delivery mode and gestational age.

Conclusions:

  • Serum sICAM-1 shows a significant rise in the first month of life in healthy neonates.
  • This indicates a progressively increasing activation of the neonatal immune system.
Abstract

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