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Lymphocyte responses to chemokines

B Moser1, M Loetscher, L Piali

  • 1Theodor Kocher Institute, University of Bern, Switzerland. bmoser@tki.unibe.ch

International Reviews of Immunology
|March 20, 1998
PubMed
Summary

Chemokines guide immune cells, but lymphocytes need activation to respond, except for SDF-1. Specific chemokines like IP10 and Mig are key for T lymphocyte migration in immune responses.

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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Chemokines are soluble proteins crucial for leukocyte recruitment to infection and inflammation sites.
  • Over three dozen human chemokines have been identified, playing vital roles in immune responses.

Purpose of the Study:

  • To review recent advancements in understanding lymphocyte responses to chemokines.
  • To highlight the role of chemokine receptor expression in lymphocyte activation and migration.

Main Methods:

  • Literature review focusing on lymphocyte-chemokine interactions.
  • Analysis of specific chemokine activities, including SDF-1, IP10, and Mig.

Main Results:

  • Lymphocyte responsiveness to chemokines generally requires prior stimulation and is linked to chemokine receptor expression.
  • SDF-1 is an exception, effectively attracting non-activated T lymphocytes and progenitor B cells.
  • IP10 and Mig chemokines are particularly important for T lymphocyte migration in T cell-dependent immune responses.

Conclusions:

  • Chemokine receptor expression and lymphocyte activation are critical for directed cell migration.
  • Specific chemokines like IP10 and Mig are key mediators in adaptive immunity.
  • While most chemokines affect multiple immune cells, some exhibit selective targeting crucial for immune regulation.

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