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Physicochemical changes in degrading polylactide films

K J Burg1, S W Shalaby

  • 1Rhodes Engineering Research Center, Department of Bioengineering, Clemson University, South Carolina, USA.

Journal of Biomaterials Science. Polymer Edition
|January 1, 1997
PubMed
Summary
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Molecular orientation significantly impacts the degradation of bioabsorbable polylactide films. Solid state uniaxial orientation (SS-UO) alters physicochemical properties, affecting degradation patterns in aqueous environments.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Materials Degradation

Background:

  • Large bioabsorbable aliphatic polyester devices exhibit heterogeneous degradation in aqueous environments.
  • Degradation often occurs from the center outwards due to autocatalysis after saturation.

Purpose of the Study:

  • To investigate the influence of molecular orientation on the degradation patterns of bioabsorbable polylactide films.
  • To examine physicochemical changes and their relation to molecular parameters during degradation.

Main Methods:

  • Development of oriented absorbable films using a novel solid-state method: solid state uniaxial orientation (SS-UO).
  • Analysis of physicochemical changes in degrading polylactide films.

Main Results:

Related Experiment Videos

  • Molecular orientation demonstrably affects the degradation pattern of polylactide films.
  • Significant changes in glass transition temperature and heat of fusion were observed due to orientation.

Conclusions:

  • Solid state uniaxial orientation is a viable method for controlling degradation characteristics of bioabsorbable films.
  • Molecular orientation plays a crucial role in the degradation behavior and thermal properties of polylactide.