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Nitric oxide in the fish gut

C Olsson¹, S Holmgren

¹Department of Zoophysiology, Göteborg University, Sweden. c.olsson@zool.gu.se

Comparative Biochemistry and Physiology. Part A, Physiology

|March 20, 1998

Summary

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Nitric oxide synthase (NOS) in fish guts shows an early evolutionary origin and inhibits motility, similar to other vertebrates. Its co-function with VIP/PACAP in fish requires further investigation.

Area of Science:

Neuroscience
Evolutionary Biology
Gastroenterology

Background:

Nitric oxide synthase (NOS)-positive nerve cells are widespread across vertebrates and some invertebrates.
This distribution suggests an early evolutionary origin for NOS and its neurotransmitter function.

Purpose of the Study:

To investigate the distribution and function of NOS in the fish gut.
To explore the potential co-function of NOS with vasoactive intestinal polypeptide (VIP)/pituitary adenylate cyclase-activating polypeptide (PACAP) in fish.

Main Methods:

Comparative analysis of NOS distribution in fish gut.
Assessment of NOS inhibitory effects on fish gut motility.
Examination of NOS co-localization with VIP/PACAP.

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Main Results:

NOS-positive nerve cells are present in the fish gut, consistent with findings in other vertebrates.
Nitric oxide exhibits an inhibitory effect on fish gut motility.
Evidence suggests potential co-existence of NOS with VIP/PACAP in fish, similar to mammals.

Conclusions:

The findings support an ancient evolutionary role for NOS in the vertebrate gut.
While general functions align with other vertebrates, species-specific variations in NOS function are likely.
Further research is needed to confirm the co-function of NOS with VIP/PACAP in fish.