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Hepatitis C virus in Zimbabwe

I T Gangaidzo1, V M Moyo, H Khumalo

  • 1Department of Medicine, University of Zimbabwe Medical School, Avondale, Harare, Zimbabwe.

The Central African Journal of Medicine
|May 1, 1997
PubMed
Summary

Hepatitis C seropositivity is common in rural Zimbabwe, affecting 7.7% of adults and causing liver damage. This prevalence is about half that of Hepatitis B carriers, highlighting Hepatitis C as a significant liver disease concern.

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Area of Science:

  • Hepatology
  • Infectious Diseases
  • Public Health

Background:

  • Hepatitis B is a known cause of chronic liver disease in Zimbabwe.
  • The prevalence of Hepatitis C virus (HCV) infection in healthy rural Zimbabwean adults was previously undescribed.
  • Other viral infections are also significant contributors to liver disease.

Purpose of the Study:

  • To determine the prevalence of Hepatitis C seropositivity in healthy rural Zimbabwean adults.
  • To assess for evidence of active liver disease in seropositive individuals.

Main Methods:

  • A cross-sectional descriptive study was conducted in rural Zimbabwean communities.
  • 150 rural Zimbabweans over 12 years of age were initially enrolled.
  • Serological markers for Hepatitis C and B, hepatic enzymes, and iron status were analyzed.

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Main Results:

  • Hepatitis C antibodies were detected in 11 (7.7%) subjects, with significant elevations in hepatic enzymes and serum iron, indicating hepatocellular damage.
  • Hepatitis B surface antigen was found in 20 (14.1%) subjects, but without significant hepatic enzyme or iron status abnormalities.
  • Hepatitis C seropositivity was approximately half the prevalence of chronic Hepatitis B carrier status.

Conclusions:

  • Hepatitis C seropositivity is a common finding in rural Zimbabwe.
  • Chronic Hepatitis C may cause more significant liver damage than chronic Hepatitis B in this population.
  • Hepatitis C is likely an important cause of liver disease in rural Zimbabwe.