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Fixed drug eruption due to amlexanox
M Sugiura1, R Hayakawa, T Osada
1Department of Dermatology, Daiko Medical Center, Nagoya University Hospital, Japan.
Contact Dermatitis
|March 20, 1998
Summary
Amlexanox, prescribed for allergic rhinitis, caused a delayed macular erythema in a patient. Patch testing confirmed amlexanox as the cause of the allergic skin reaction.
Area of Science:
- Dermatology
- Allergology
- Pharmacology
Background:
- Allergic rhinitis is a common condition often treated with oral medications.
- Amlexanox and lysozyme chloride are ingredients found in some allergy medications.
Observation:
- A 23-year-old woman developed allergic rhinitis and was prescribed amlexanox (Solfa) and lysozyme chloride (Lysozymen 90).
- Approximately one year after starting the medication, she developed a macular erythema on her buttocks.
Findings:
- Patch testing revealed a positive reaction to amlexanox (Solfa 50% pet.) specifically on the affected skin area.
- No reaction was observed with lysozyme chloride (Lysozymen 90, 50% pet.) on either affected or unaffected skin.
- An open application test with amlexanox confirmed it as the causative agent for the erythema.
Implications:
- This case highlights amlexanox as a potential allergen causing delayed cutaneous reactions.
- Physicians should consider drug-induced erythema in patients presenting with unexplained skin lesions after initiating new medications.
- Further investigation into amlexanox hypersensitivity is warranted.