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Neuroanatomic localization of magnetic resonance imaging signal hyperintensities in geriatric depression
B S Greenwald1, E Kramer-Ginsberg, K R Krishnan
1Department of Psychiatry, Long Island Jewish Medical Center, Glen Oaks, NY 11004, USA. greenwal@lij.edu
Background And Purpose:
Increased frequency and severity of signal hyperintensities have been regularly reported in elderly depressed patients compared with normal subjects, however, greater neuroanatomic localization of lesions has been limited.
Methods:
T2-weighted MRI scans in elderly depressed patients (n = 35) and normal comparison subjects (n = 31) were assessed for signal hyperintensities in lateralized discrete brain regions.
Results:
Logistic regression revealed that left frontal deep white matter (P<.005) and left putaminal (P<.04) hyperintensities significantly predicted depressive group assignment.
Conclusions:
Findings suggest that greater neuroanatomic localization of hyperintensities than heretofore appreciated may relate to late-life depression.
