Related Experiment Video
Updated: Aug 13, 2026
13:21
Chemically-blocked Antibody Microarray for Multiplexed High-throughput Profiling of Specific Protein Glycosylation in Complex Samples
Published on: May 4, 2012
Liver function tests and electrophoretic pattern of serum protein in hepatic amoebiasis
The Journal of Tropical Medicine and Hygiene
|June 1, 1976
Summary
Hepatic amoebiasis patients consistently showed low albumin and high alpha2 globulins. Lactate dehydrogenase (LDH) enzyme levels were elevated in amoebic liver abscess cases, indicating liver damage.
Area of Science:
- Hepatology
- Infectious Diseases
- Clinical Biochemistry
Background:
- Hepatic amoebiasis is a significant parasitic infection affecting the liver.
- Understanding the biochemical markers associated with this condition is crucial for diagnosis and management.
Purpose of the Study:
- To review liver function tests and serum protein electrophoresis patterns in patients with hepatic amoebiasis.
- To identify consistent biochemical abnormalities associated with amoebic liver disease.
Main Methods:
- Retrospective review of 11 patients with hepatic amoebiasis.
- Analysis of liver function tests and serum protein electrophoretic patterns.
- Measurement of lactate dehydrogenase (LDH) enzyme levels.
Main Results:
- A consistent pattern of hypoalbuminemia (low albumin) was observed in all patients.
- Elevated alpha2 globulins were a constant finding in the serum protein electrophoresis.
- Raised LDH enzyme levels were noted in all cases of amoebic liver abscess.
Conclusions:
- Hypoalbuminemia and elevated alpha2 globulins are characteristic biochemical markers of hepatic amoebiasis.
- Elevated LDH levels are indicative of liver tissue damage in amoebic liver abscess.
- These findings aid in the diagnosis and understanding of the pathogenesis of hepatic amoebiasis.
Related Concept Videos
01:30Serum Laboratory Studies, Stool Test, Breath Test
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
01:26Nephrotic Syndrome II : Assessment and Medical Management
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
01:24Serum Studies: Renal Function Tests
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
01:28Amebiasis
Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
01:29Hepatic Encephalopathy
DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...