Related Experiment Video
Updated: Aug 5, 2026
07:42
An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
Published on: July 1, 2020
Candida funisitis: A clinicopathologic study of 32 cases
F Qureshi1, S M Jacques, R W Bendon
1Department of Pathology, Hutzel Hospital, 4707 St. Antoine Boulevard, Detroit, MI 48201, USA.
Summary
Candida funisitis, an umbilical cord infection, often co-occurs with chorioamnionitis and prematurity. Prompt diagnosis is crucial for identifying potential fetal infections beyond congenital candidiasis.
Area of Science:
- Medical Mycology
- Perinatology
- Pathology
Background:
- Candida funisitis is a rare umbilical cord infection.
- It is associated with adverse perinatal outcomes.
Purpose of the Study:
- To describe the clinicopathologic features of Candida funisitis.
- To identify associated risk factors and outcomes.
Main Methods:
- Retrospective case series analysis.
- Review of 32 cases of Candida funisitis.
- Clinicopathologic correlation.
Main Results:
- Candida funisitis presented as yellow-white nodules on the umbilical cord.
- All cases had coexisting chorioamnionitis.
- 75% of affected infants were premature, with 7 perinatal deaths.
- Congenital candidiasis occurred in 16% of fetuses.
- Intrauterine foreign bodies were noted in 16% of mothers.
Conclusions:
- Candida funisitis diagnosis necessitates thorough fetal infection evaluation.
- The condition is strongly linked to chorioamnionitis and prematurity.
- Congenital candidiasis is not always present, despite the fungal origin.
Related Concept Videos
01:27Cryptococcal Meningitis
Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
01:20Candidiasis
Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...