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Neuropeptide Y antibody attenuates 2-deoxy-D-glucose induced feeding in rats
1Department of Foods and Nutrition, University of Georgia, Athens, GA 30602, USA.
Brain Research
|May 2, 1998
Abstract:
2-deoxy-D-glucose (2-DG) has been shown to induce increased feeding responses in animals. Recent studies suggest the possible involvement of neuropeptide Y (NPY) in 2-DG-induced feeding. The present study examined the effect of immunoneutralization of endogenous NPY on 2-DG-induced feeding. NPY antibody injected into the paraventricular nucleus of the rats significantly attenuated 2-DG-induced feeding, suggesting that hypothalamic NPY may mediate, at least partly, the effect of 2-DG on food intake.