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Adrenoceptors affect accommodation by modulating cholinergic activity

N Otsuka1, T Yoshitomi, K Tsuchiya

  • 1Department of Ophthalmology, Kitasato University School of Medicine, Kanagawa, Japan.

Japanese Journal of Ophthalmology
|March 21, 1998
PubMed
Summary
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Adrenergic agents influence accommodation by affecting the eye's focusing ability. Alpha adrenoceptor activation impacts the near point, while beta adrenoceptor activation influences accommodative adaptation, suggesting a role in visual function.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Pharmacology

Background:

  • Adrenoceptors play a role in various physiological processes.
  • The specific function of adrenoceptors in the eye's accommodation mechanism requires further elucidation.

Purpose of the Study:

  • To investigate the functional role of alpha and beta adrenoceptors in human accommodation.
  • To determine the effects of specific adrenergic agents on accommodation parameters.

Main Methods:

  • Fifty-two visually normal subjects underwent accommodation testing.
  • Quasistatic measurement of far and near points of accommodation, tonic accommodation, and accommodative adaptation.
  • Assessment before and after topical application of adrenergic agents like bunazosin, phenylephrine, timolol, and isoproterenol.

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Main Results:

  • Bunazosin hydrochloride (alpha-agonist) increased the near point of accommodation.
  • Isoproterenol hydrochloride (beta-agonist) caused a hyperopic shift in the far point.
  • Timolol maleate (beta-blocker) increased accommodative adaptation, while isoproterenol decreased it.

Conclusions:

  • Both alpha and beta adrenoceptors significantly influence accommodation.
  • Activation of alpha adrenoceptors affects the near point, and beta adrenoceptors modulate accommodative adaptation.
  • Adrenoceptor activity may alter parasympathetic activity, thereby impacting the accommodative state.